Basic Information
| LncRNA/CircRNA Name | PCA3 |
| Synonyms | DD3 |
| Region | GRCh38_9:76691980-76863307 |
| Ensemble | ENSG00000225937 |
| Refseq | NR_015342 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, etc. |
| Sample | prostate carcinoma tissues, Human embryo kidney cell line HEK-293, human PCa cell lines LNCaP/PC-3/Du-145, and normal prostate epithelial cell line RWPE-1 |
| Expression Pattern | up-regulated |
| Function Description | PCA3 and HMGB1 were high expressed in PCa, whereas miR 218 5p was lowexpressed. PCA3 knockdown or miR 218 5p overexpression suppressed PCa cell proliferation, migration, and invasion, but promoted apoptosis. Besides, targeted relationships and interactions on the expression between miR 218 5p and PCA3 or HMGB1 were elucidated. PCA3 weakened cell viability and mobility whereas induced apoptosis through binding with miR 218 5p. Meanwhile, miR 218 5p also inhibited PCa tumorigenesis via downregulation of HMGB1. Knockdown of PCA3 impeded tumor growth by downregulating its downstream gene HMGB1. |
| Pubmed ID | 30569456 |
| Year | 2018 |
| Title | Long noncoding RNA PCA3 regulates prostate cancer through sponging miR-218-5p and modulating high mobility group box 1. |
External Links
| Links for PCA3 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |