Basic Information
| LncRNA/CircRNA Name | BCAR4 |
| Synonyms | NA |
| Region | GRCh38_16:11819829-11828845 |
| Ensemble | ENSG00000262117 |
| Refseq | NR_024049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | anti-estrogen,Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay, Western blot |
| Sample | colorectal cancer tissues,CRC cell lines (HCT-116, SW480, HCT-8) |
| Expression Pattern | up-regulated |
| Function Description | As expected, qRTPCR results showed BCAR4 expression was signifcantly up-regulated ,we found that BCAR4 was signifcantly upregulated in the ALDH+ cells and the expression level of BCAR4 was consistent with CD133 and SOX2 which were the markers of CSC in CRC. |
| Pubmed ID | 30962766 |
| Year | 2019 |
| Title | LncRNA BCAR4, targeting to miR-665/STAT3 signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal cancer. |
External Links
| Links for BCAR4 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |