Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | RT-PCR , Western blot , in vitro knockdown etc. |
| Sample | tumor and adjacent tissues ,EC cell lines (HEC-1B, Ishikawa, RL95-2, and AN3CA ) ,normal endometrial stromal cell line ESC |
| Expression Pattern | up-regulated |
| Function Description | We found elevated expression levels of PCAT1 in EC tissues and cell lines. Higher PCAT1 expression was positively correlated with FIGO stage, myometrial invasion, lymph node metastasis, and a shorter overall survival.knockdown of PCAT1 by small interfering RNA (siRNA) targeting PCAT1 (siPCAT1) suppressed cell proliferation, migration and invasion, but promoted apoptosis.B-cell lymphoma 2 (Bcl-2), vimentin and N-cadherin were downregulated, but E-cadherin and Bcl-2-associated death promoter (Bad) were upregulated in PCAT1-silenced EC cells. |
| Pubmed ID | 31136293 |
| Year | 2019 |
| Title | PCAT1 Is a Poor Prognostic Factor in Endometrial Carcinoma and Associated With Cancer Cell Proliferation, Migration and Invasion |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |