Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | acute myeloid leukemia |
| ICD-0-3 | NA |
| Methods | RT-qPCR, RIP, Dual luciferase assay, Western blot |
| Sample | Bone marrow samples,AML cell lines (Kasumi-6, HL-60, MOLT-3, AML-193 and BDCM) and human bone marrow stromal cells (HS-5) |
| Expression Pattern | up-regulated |
| Function Description | PCAT-1 was highly expressed in AML-M1/2 and AML-M3 patients than normal controls.The functional experiments demonstrated that knockdown of PCAT-1 remarkably inhibited proliferation, arrested cell cycle progression and triggered apoptosis of AML cells. Mechanistically, we revealed that PCAT-1 could directly interact with FZD6 protein to regulate its stability. PCAT-1 could activate the Wnt/?-catenin signaling pathway in an FZD6-dependent manner. |
| Pubmed ID | 31814913 |
| Year | 2019 |
| Title | lncRNA PCAT-1 Interacting With FZD6 Contributes to the Malignancy of Acute Myeloid Leukemia Cells Through Activating Wnt/?-catenin Signaling Pathway |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for acute myeloid leukemia | OMIM COSMIC |