Detail

Basic Information

LncRNA/CircRNA Name	PCAT1
Synonyms	LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1
Region	GRCh38_8:126556323-127419050
Ensemble	ENSG00000253438
Refseq	NR_045262

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	non small cell lung cancer
ICD-0-3	C34
Methods	qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, RIP, etc.
Sample	primary NSCLC tissues, NSCLC cell lines
Expression Pattern	up-regulated
Function Description	the higher expression of PCAT 1 led to a significantly poorer survival time, and multivariate analysis revealed that PCAT 1 was an independent risk factor of prognosis in NSCLC. Furthermore, we also found that the knockdown of PCAT 1 remarkably suppressed cell growth by inducing cell cycle arrest and apoptosis promotion in NSCLC cells. Moreover, the bioinformatics analysis and luciferase reporter assay revealed that PCAT 1 directly bound to the miR 149 5p, which has been reported to act as a tumor suppressor in diverse cancers. In addition, our results confirmed that the tumor promoting effects of PCAT 1 in NSCLC cells are at least partly through negative modulation of miR 149 5p. Finally, mechanistic investigations showed that PCAT 1 upregulated the expression of miR 149 5p target gene leucine rich repeats and immunoglobulin (Ig) like domains 2 (LRIG2) through competitively spongeing miR 149 5p. Therefore, we concluded that PCAT 1 may promote the development of NSCLC through the miR 149 5p/LRIG2 axis.
Pubmed ID	30569478
Year	2019
Title	LncRNA-PCAT-1 promotes non-small cell lung cancer progression by regulating miR-149-5p/LRIG2 axis.

External Links

Links for PCAT1	GenBank HGNC NONCODE
Links for non small cell lung cancer	OMIM COSMIC