Basic Information
| LncRNA/CircRNA Name | PCAT1 |
| Synonyms | LPCAT1, AGPAT10, AGPAT9, AYTL2, LPCAT-1, PFAAP3, lpcat, lysoPAFAT, PCAT-1 |
| Region | GRCh38_8:126556323-127419050 |
| Ensemble | ENSG00000253438 |
| Refseq | NR_045262 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | Microarray, qPCR, RNAi, Western blot, Luciferase reporter assay etc. |
| Sample | prostate tissues, cell lines (Du145-derived, RWPE-derived, LNCAP-derived, PC3-derived etc.) |
| Expression Pattern | up-regulated |
| Function Description | PCAT-1 overexpression in Du145 prostate cancer cells (which lack endogenous expression of this lncRNA),PCAT-1 overexpression in RWPE benign prostate cells (which lack endogenous expression of this lncRNA), and stable knockdown of PCAT-1 in LNCaP prostate cancer cells (which harbor high endogenous levels of PCAT-1 expression). |
| Pubmed ID | 24473064 |
| Year | 2014 |
| Title | PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. |
External Links
| Links for PCAT1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |