Basic Information
| LncRNA/CircRNA Name | PCAT14 |
| Synonyms | PCAT14 |
| Region | GRCh38_22:23536881-23547797 |
| Ensemble | ENSG00000280623 |
| Refseq | NR_109832 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot etc. |
| Sample | hepatocellular carcinoma tissues, cell lines (Huh7, HCCLM3, HepG2, SMMC7721, PLC5, and QGY7701) |
| Expression Pattern | up-regulated |
| Function Description | the lncRNA PCAT-14 is overexpressed in patients with hepatocellular carcinoma (HCC), and is associated with a poor prognosis after surgery. In addition, PCAT-14 inhibits miR-372 expression by inducing methylation of the miR-372 promoter. |
| Pubmed ID | 28415780 |
| Year | 2017 |
| Title | Long noncoding RNA PCAT-14 induces proliferation and invasion by hepatocellular carcinoma cells by inducing methylation of miR-372 |
External Links
| Links for PCAT14 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |