Basic Information
| LncRNA/CircRNA Name | PCAT5 |
| Synonyms | PCAT5, LINC01452, TPCAT-10-36067 |
| Region | GRCh38_10:35778302-35800920 |
| Ensemble | ENSG00000280719 |
| Refseq | NR_110138 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RNA-seq, qPCR, RNAi etc. |
| Sample | cell lines (PC-3, 22Rv1) |
| Expression Pattern | up-regulated |
| Function Description | In vitro validation of these alterations revealed a complex integrated phenotype affecting cell growth, migration, invasion, colony-forming potential and apoptosis. Our findings reveal a key molecular determinant of differences between PC and CRPC at the level of the transcriptome. Further, they establish PCAT5 as a novel oncogenic lncRNA in ERG-positive prostate cancers, with implications for defining CRPC biomarkers and new therapeutic interventions. |
| Pubmed ID | 26282172 |
| Year | 2015 |
| Title | Transcriptome sequencing reveals PCAT5 as a novel ERG-regulated long non-coding RNA in prostate cancer. |
External Links
| Links for PCAT5 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |