Basic Information
| LncRNA/CircRNA Name | PCAT6 |
| Synonyms | NA |
| Region | GRCh38_1:202810954-202812156 |
| Ensemble | ENSG00000228288 |
| Refseq | NR_046325 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot |
| Sample | Human ovarian cancer cells including SKOV3, OVCAR3, PEO1, A2780, 3AO, CAOV3 and one normal human ovarian surface epithelial cells (HOSEPiCs), ovarian cancer tissues, paracancerous tissues |
| Expression Pattern | up-regulated |
| Function Description | the expression level of PCAT6 in ovarian cancer was higher than that in the adjacent normal tissues. The incidence of distant metastasis and lymph node metastasis in patients with high expression of PCAT6 was higher than those with low PCAT6 expression. Compared with the NC group, the proliferation, metastasis and invasion ability of ovarian cancer cells in si-PCAT6 group decreased significantly. QRT-PCR results demonstrated that the PTEN expression was increased after the knockdown of PCAT6. In addition, the recovery experiment also revealed that PCAT6 and PTEN have a mutual regulation, which can jointly regulate the development of ovarian cancer. |
| Pubmed ID | 31646553 |
| Year | 2019 |
| Title | LncRNA PCAT6 promotes occurrence and development of ovarian cancer by inhibiting PTEN |
External Links
| Links for PCAT6 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |