Basic Information
| LncRNA/CircRNA Name | PCGEM1 |
| Synonyms | NA |
| Region | GRCh38_2:192749845-192776899 |
| Ensemble | ENSG00000227418 |
| Refseq | NR_002769 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cancer |
| ICD-0-3 | C64.9 |
| Methods | qRT-PCR, Microarray, Luciferase reporter assay, RIP |
| Sample | cell lines (OSRC-682, ACHN, A498 and 786O,HK-2) ,tissue samples |
| Expression Pattern | up-regulated |
| Function Description | PCGEM1 was observed to be lifted in renal carcinoma cells. Loss-of-function experiments displayed that silencing of PCGEM1 repressed cell proliferation and migration, and activated apoptosis in renal carcinoma.PCGEM1 interacted with microRNA433-3p (miR-433-3p). PCGEM1 and fibroblast growth factor 2 (FGF2) functioned as ceRNA for miR-433-3p, leading to the upregulation of FGF2 expression. |
| Pubmed ID | 31958075 |
| Year | 2020 |
| Title | LncRNA PCGEM1 Promotes Renal Carcinoma Progression by Targeting miR-433-3p to Regulate FGF2 Expression |
External Links
| Links for PCGEM1 | GenBank HGNC NONCODE |
| Links for renal cancer | OMIM COSMIC |