Basic Information
| LncRNA/CircRNA Name | PCGEM1 |
| Synonyms | PCGEM1, LINC00071, NCRNA00071, PCAT9 |
| Region | GRCh38_2:192749845-192776899 |
| Ensemble | ENSG00000227418 |
| Refseq | NR_002769 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR etc. |
| Sample | prostate cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | Here, we demonstrate that PCGEM1 expression is significantly higher in prostate cancer (CaP) cells of African-American men than in Caucasian-American men. Further, increased PCGEM1 expression associates with normal prostate epithelial cells of CaP patients with a family history of CaP. PCGEM1 overexpression in LNCaP and in NIH3T3 cells promotes cell proliferation and a dramatic increase in colony formation, suggesting a biological role of PCGEM1 in cell growth regulation. |
| Pubmed ID | 14724589 |
| Year | 2004 |
| Title | Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. |
External Links
| Links for PCGEM1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |