Basic Information
| LncRNA/CircRNA Name | PCGEM1 |
| Synonyms | PCGEM1, LINC00071, NCRNA00071, PCAT9 |
| Region | GRCh38_2:192749845-192776899 |
| Ensemble | ENSG00000227418 |
| Refseq | NR_002769 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RNA-seq, qPCR etc. |
| Sample | primary prostate cancer tissues, cell lines (LNCaP, 22RV1, VCaP) |
| Expression Pattern | up-regulated |
| Function Description | RNA sequencing of two distinct androgen-dependent models shows PCGEM1 to be considerably expressed, while PRNCR1 showed scant basal expression. PCGEM1 was sharply down-regulated following castration and up-regulated upon AR activation in vivo. A PCGEM1-associated gene expression signature (PES) was significantly repressed in response to androgen ablation therapy and in hormone-refractory versus hormone-nave PCa patients. Furthermore, we found PCGEM1 was uniformly distributed in PCa cell nucleus and cytoplasm which remained unaltered upon AR transcriptional activation. PCGEM1 was up-regulated in primary PCa but not in metastasized PCa. |
| Pubmed ID | 25744782 |
| Year | 2015 |
| Title | The long non-coding RNA PCGEM1 is regulated by androgen receptor activity in vivo. |
External Links
| Links for PCGEM1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |