Basic Information
| LncRNA/CircRNA Name | PDCD4-AS1 |
| Synonyms | NA |
| Region | GRCh38_10:110869868-110872233 |
| Ensemble | ENSG00000203497 |
| Refseq | NR_026932 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, in vitro knockdown, RIP, etc. |
| Sample | M1 cell(MCF10A),M2 cell(MCF10AT1k.cl2),M3 cell(MCF10Ca1h) and M4 (MCF10CA1a.cl1) |
| Expression Pattern | down-regulated |
| Function Description | PDCD4-AS1 lncRNA reveal that it positively regulates the expression and activity of the tumor suppressor PDCD4 in mammary epithelial cells. Both PDCD4-AS1 and PDCD4 show reduced expression in TNBC cell lines and in patients, and depletion of PDCD4-AS1 compromised the cellular levels and activity of PDCD4. Further, tumorigenic properties of PDCD4-AS1-depleted TNBC cells were rescued by exogenous expression of PDCD4, implying that PDCD4-AS1 acts upstream of PDCD4. Mechanistically, PDCD4-AS1 stabilizes PDCD4 RNA by forming RNA duplex and controls the interaction between PDCD4 RNA and RNA decay promoting factors such as HuR. |
| Pubmed ID | 30496290 |
| Year | 2018 |
| Title | A natural antisense lncRNA controls breast cancer progression by promoting tumor suppressor gene mRNA stability |
External Links
| Links for PDCD4-AS1 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |