Basic Information
| LncRNA/CircRNA Name | PENG |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP etc. |
| Sample | ccRCC tissues and corresponding adjacent normal tissues, cell lines(HEK293, ACHN, and 769-P) |
| Expression Pattern | down-regulated |
| Function Description | Conversely, a novel lncRNA (lncPENG) was expressed at a lower level in ccRCC tissues, and its downregulation was associated with the same effects as upregulation of miR-15b. Downregulation of miR-15b and upregulation of lncPENG resulted in a significant increase in PDZK1 level and inhibition of proliferation in vitro and in vivo. |
| Pubmed ID | 32341409 |
| Year | 2020 |
| Title | Long noncoding RNA PENG upregulates PDZK1 expression by sponging miR-15b to suppress clear cell renal cell carcinoma cell proliferation. |
External Links
| Links for PENG | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |