Basic Information
| LncRNA/CircRNA Name | PGM5-AS1 |
| Synonyms | NA |
| Region | GRCh38_9:68355189-68357852 |
| Ensemble | ENSG00000224958 |
| Refseq | NR_015423 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Luciferase reporter assay etc |
| Sample | CRC tissues and normal tissue, cell lines(HIEC, SW480, HT29, HCT116, Caco-2, and LoVo) |
| Expression Pattern | up-regulated |
| Function Description | PGM5-AS1 was upregulated in CRC tissues and cell lines; however, its downregulation contributed to the decreasing of cell viability, growth, migration, and invasion of SW480 and HCT116 cells. Moreover, miR-484 was predicted as the target of PGM5-AS1, and the downregulation of PGM5-AS1 partially restored the elevated cell viability, growth, migration, and invasion that were induced by the inhibition of miR-484 expression in SW480 and HCT116 cells. |
| Pubmed ID | 32354224 |
| Year | 2020 |
| Title | The Downregulation of lncRNA PGM5-AS1 Inhibits the Proliferation and Metastasis Via Increasing miR-484 Expression in Colorectal Cancer. |
External Links
| Links for PGM5-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |