Basic Information
| LncRNA/CircRNA Name | PGM5-AS1 |
| Synonyms | PGM5 antisense RNA 1 |
| Region | GRCh38_9:68355189-68357852 |
| Ensemble | ENSG00000224958 |
| Refseq | NR_015423 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qRT-PCR |
| Sample | ccRCC tissues |
| Expression Pattern | down-regulated |
| Function Description | The expressions of PGM5-AS1 in cancer specimens were lower than those in matched non-tumor specimens from the ccRCC patient (p<0.05). Downregulation of PGM5-AS1 was closely associated with more advanced clinical features, including lymph nodes metastasis (p=0.007) and distant metastasis (p=0.037). A clinical study revealed that ccRCC patients with lower PGM5-AS1 expressions had substantially shorter overall survival (OS) and disease-free survival (DFS) than patients with higher PGM5-AS1 expressions. |
| Pubmed ID | 31858536 |
| Year | 2019 |
| Title | Down-regulation of Long Noncoding RNA PGM5-AS1 Correlates With Tumor Progression and Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma |
External Links
| Links for PGM5-AS1 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |