Basic Information
| LncRNA/CircRNA Name | PiHL |
| Synonyms | P53 inHibiting LncRNA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | RIP, RNA-seq, qRT-PCR, Western blot |
| Sample | primary cancer tissues,SW620, LoVo, HT-29, SW480, HCT116, RKO CRC cell lines and HEK-293T cells,The isogenic p53-WT and p53-null HCT116 and RKO cells |
| Expression Pattern | up-regulated |
| Function Description | PiHL is drastically upregulated in CRC and is an independent predictor of CRC poor prognosis. Further in vitro and in vivo models demonstrated that PiHL was crucial in maintaining cell proliferation and inducing 5-FU chemoresistance through a p53-dependent manner. Mechanistically, PiHL acts to promote p53 ubiquitination by sequestering RPL11 from MDM2, through enhancing GRWD1 and RPL11 complex formation. |
| Pubmed ID | 31903119 |
| Year | 2020 |
| Title | Long Noncoding RNA PiHL Regulates p53 Protein Stability Through GRWD1/RPL11/MDM2 Axis in Colorectal Cancer |
External Links
| Links for PiHL | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |