Basic Information
| LncRNA/CircRNA Name | PITPNA-AS1 |
| Synonyms | PITPNA antisense RNA 1 |
| Region | GRCh38_17:1516931-1518096 |
| Ensemble | ENSG00000236618 |
| Refseq | NR_028514 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Luciferase Reporter Assay, RIP, Western blot |
| Sample | HCC and adjacent normal tissues,HCC cells containing HepG2, SMMC-7721, HCCLM3, and Hep3B, normal hepatocyte line L02 and human embryonic kidney (HEK) 293T cells |
| Expression Pattern | up-regulated |
| Function Description | PITPNA-AS1 was observed to be heightened in HCC tissues. Then function assays proved that overexpressing or silencing PITPNA-AS1 could manipulate the proliferation and motility of HCC cells. Besides, PITPNA-AS1 was located in the cytoplasm.mechanism experiments validated that PITPNA-AS1 modulated WNT5A expression by targeting miR-876-5p. Rescue experiments affirmed that WNT5A silencing rescued the miR-876-5p suppression-induced cellular processes in PITPNA-AS1-silenced Hep3B cells. |
| Pubmed ID | 31700026 |
| Year | 2019 |
| Title | PITPNA-AS1 Abrogates the Inhibition of miR-876-5p on WNT5A to Facilitate Hepatocellular Carcinoma Progression |
External Links
| Links for PITPNA-AS1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |