Basic Information
| LncRNA/CircRNA Name | PLAC2 |
| Synonyms | TINCR, FLJ90734, LINC00036, NCRNA00036, onco-lncRNA-16 |
| Region | GRCh38_19:5558167-5578349 |
| Ensemble | ENSG00000223573 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, etc. |
| Sample | NSCLC tissues, human NSCLC cell lines (H650, H1581) |
| Expression Pattern | down-regulated |
| Function Description | PLAC2 was down-regulated, while miR-21 was up-regulated in NSCLC tissues compared to non-cancer tissues. Low PLAC2 levels in NSCLC tissues were associated with poor survival of NSCLC patients. PLAC2 and miR-21 were inversely correlated, and PLAC 2 over-expression in NSCLC cells resulted in the down-regulation of miR-21. However, miR-21 over-expression did not significantly affect PLAC2 expression. In addition, PLAC2 over-expression resulted in decreased migration and invasion rates of NSCLC cells. MiR-21 over-expression played the opposite role and attenuated the effects of PLAC2 over-expression. |
| Pubmed ID | 31500623 |
| Year | 2019 |
| Title | LncRNA PLAC 2 downregulated miR-21 in non-small cell lung cancer and predicted survival |
External Links
| Links for PLAC2 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |