Basic Information
| LncRNA/CircRNA Name | PLAC2 |
| Synonyms | TINCR, FLJ90734, LINC00036, NCRNA00036, onco-lncRNA-16 |
| Region | GRCh38_19:5558167-5578349 |
| Ensemble | ENSG00000223573 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Luciferase reporter assay, Western blot, RIP, RNAi |
| Sample | glioma tissues, cell lines (U87MG and U251) |
| Expression Pattern | differential expression |
| Function Description | PLAC2 induces cell cycle arrest by targeting ribosomal protein (RP)L36 in glioma.RPL36 promoted cell proliferation and G1/S cell cycle progression. signal transducer and activator of transcription (STAT)1 interacted with both lncRNA PLAC2 and the RPL36 promoter.the nucleus PLAC2 bind with STAT1 and interact with RPL36 promoters but the cytoplasmic lncRNA PLAC2 inhibited STAT1 nuclear transfer, thereby decreasing RP36 expression, inhibiting cell proliferation and inducing cell cycle arrest. |
| Pubmed ID | 28922548 |
| Year | 2017 |
| Title | LncRNA PLAC2 down-regulates RPL36 expression and blocks cell cycle progression in glioma through a mechanism involving STAT1. |
External Links
| Links for PLAC2 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |