Basic Information
| LncRNA/CircRNA Name | PlncRNA-1 |
| Synonyms | CBR3-AS1, PlncRNA-1, PlncRNA1 |
| Region | GRCh38_21:36131767-36175815 |
| Ensemble | ENSG00000236830 |
| Refseq | NR_038892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, RNAi etc. |
| Sample | ESCC tissues, cell lines (KYSE30, KYSE70, KYSE140, KYSE150, KYSE180 etc.) |
| Expression Pattern | up-regulated |
| Function Description | The expression of PlncRNA-1 was significantly higher in human ESCC compared with the adjacent noncancerous tissues, and the high level of PlncRNA-1 expression was significantly correlated with advanced clinical stage and lymph node metastasis. Furthermore, knockdown of PlncRNA-1 reduced cell proliferation and increased the apoptosis in vitro. |
| Pubmed ID | 24337686 |
| Year | 2014 |
| Title | Upregulation of the long non-coding RNA PlncRNA-1 promotes esophageal squamous carcinoma cell proliferation and correlates with advanced clinical stage. |
External Links
| Links for PlncRNA-1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |