Basic Information
| LncRNA/CircRNA Name | PRKCZ-AS1 |
| Synonyms | NA |
| Region | GRCh38_1:2181794-2184389 |
| Ensemble | ENSG00000182873 |
| Refseq | NR_146290 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | RT-qPCR, Western blot assay, RIP, Luciferase reporter assay |
| Sample | LUAD tissues ,LUAD cell lines (H1299, PC-9, A549 and SPC-A1), and normal human lung epithelial cell line (HBE) |
| Expression Pattern | up-regulated |
| Function Description | the expression of PRKCZ-AS1 in LUAD tissues and cell lines was notably upregulated. Moreover, knockdown of PRKCZ-AS1 inhibited the proliferation and migration, but promoted apoptosis in LUAD cells. Furthermore, miR-766-5p could bind with PRKCZ-AS1. Besides, the expression miR-766-5p was negatively regulated by PRKCZ-AS1 expression in LUAD cells. |
| Pubmed ID | 31939714 |
| Year | 2020 |
| Title | PRKCZ-AS1 Promotes the Tumorigenesis of Lung Adenocarcinoma via Sponging miR-766-5p to Modulate MAPK1 |
External Links
| Links for PRKCZ-AS1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |