Basic Information
| LncRNA/CircRNA Name | PRNCR1 |
| Synonyms | NA |
| Region | GRCh38_8:127079874-127092600 |
| Ensemble | ENSG00000282961 |
| Refseq | NR_109833 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot etc |
| Sample | breast cancer tissues,cell lines ( MCF-10A, BT-549, MCF-7, SK-BR-3 and MDA-MB-231) |
| Expression Pattern | up-regulated |
| Function Description | In vitro experiments determined that PRNCR1 was significantly upregulated in the breast cancer cell lines BT-549, MCF-7, SK-BR-3 and MDA-MB-231 compared with the normal human breast cell line, MCF-10A. Silencing of PRNCR1 significantly inhibited the proliferation, colony formation, cell cycle progression, migration and invasion of SK-BR-3 and BT-549 cells, while cell apoptosis was induced. In addition, knockdown of PRNCR1 suppressed epithelial-mesenchymal transition in SK-BR-3 and BT-549 cells. |
| Pubmed ID | 31798697 |
| Year | 2019 |
| Title | Long Non-Coding RNA PRNCR1 Has an Oncogenic Role in Breast Cancer |
External Links
| Links for PRNCR1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |