Basic Information
| LncRNA/CircRNA Name | PRNCR1 |
| Synonyms | prostate cancer non-coding RNA 1 |
| Region | GRCh38_8:127079874-127092600 |
| Ensemble | ENSG00000282961 |
| Refseq | NR_109833 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qRT-PCR, Western blot, Dual luciferase reporter assay, RIP |
| Sample | NSCLC and paired para-carcinoma tissues,NSCLC cell lines, such as SPC-A1 and A549, and control of Normal human lung epithelial cells BEAS-2B |
| Expression Pattern | up-regulated |
| Function Description | PRNCR1 and MTDH levels were high, while miR-126-5p expression was low in NSCLC tissues and cell lines. Knockdown of PRNCR1 promoted cell apoptosis, impeded proliferation, migration, invasion and epithelial-mesenchymal transition (EMT) in NSCLC cells, and these effects were abrogated by its target gene of miR-126-5p inhibitor.PRNCR1 and miR-126-5p regulated MTDH expression. |
| Pubmed ID | 31912882 |
| Year | 2020 |
| Title | Long Non-Coding RNA PRNCR1 Modulates Non-Small Cell Lung Cancer Cells Proliferation, Apoptosis, Migration, Invasion and EMT Through PRNCR1/miR-126-5p/MTDH Axis |
External Links
| Links for PRNCR1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |