Basic Information
| LncRNA/CircRNA Name | PSMB8-AS1 |
| Synonyms | NA |
| Region | GRCh38_6:32844086-32846495 |
| Ensemble | ENSG00000204261 |
| Refseq | NR_037173 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, RIP |
| Sample | astrocytes (NHA) and glioma cells (U251, U87, SHG44, A172) |
| Expression Pattern | up-regulated |
| Function Description | the expression of PSMB8-AS1 was dramatically upregulated in glioma tissues and cells, further, PSMB8-AS1 silencing restrained cell proliferation in glioma, and the results of PSMB8-AS1 overexpression were opposite.PSMB8-AS1 could bind with miR-574-5p, which was low expressed in glioma cells.ELK1, a transcription factor, could active PSMB8-AS1 expression. |
| Pubmed ID | 31812014 |
| Year | 2020 |
| Title | PSMB8-AS1 Activated by ELK1 Promotes Cell Proliferation in Glioma via Regulating miR-574-5p/RAB10 |
External Links
| Links for PSMB8-AS1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |