Basic Information
| LncRNA/CircRNA Name | PSMG3-AS1 |
| Synonyms | PSMG3-antisense (AS)1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RT-qPCR, Western blot analysis |
| Sample | breast cancer tissue,breast epithelial cells MCF-10A and the breast cancer cell lines MDA-MB-468, MDA-MB-231 and MCF-7 |
| Expression Pattern | up-regulated |
| Function Description | PSMG3-AS1 expression was increased in breast cancer tumor tissues and cell lines, and that of miR-143-3p was decreased. Knockdown of PSMG3-AS1 increased the level of miR-143-3p expression, which led to the mitigation of proliferation and migration capacity in breast carcinoma cells. Additionally, PSMG3-AS1 knockdown was demonstrated to reduce the mRNA and protein expression levels of COL1A1. |
| Pubmed ID | 31661146 |
| Year | 2020 |
| Title | Novel lncRNA PSMG3-AS1 Functions as a miR-143-3p Sponge to Increase the Proliferation and Migration of Breast Cancer Cells |
External Links
| Links for PSMG3-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |