Basic Information
| LncRNA/CircRNA Name | PTAL |
| Synonyms | AC004988.1 |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | RT-PCR, Western blotting |
| Sample | OvCa cell lines A2780 and SKOV3 |
| Expression Pattern | up-regulated |
| Function Description | PTAL was significantly upregulated in mesenchymal subtype samples compared with epithelial subtype samples from TCGA serous OvCa datasets.knockdown of PTAL inhibited cell migration and invasion and blunted the progression of metastasis in vitro. Meanwhile, knockdown of PTAL increased the expression of miR-101 and subsequently inhibited the expression of FN1. |
| Pubmed ID | 31930166 |
| Year | 2019 |
| Title | A PTAL-miR-101-FN1 Axis Promotes EMT and Invasion-Metastasis in Serous Ovarian Cancer |
External Links
| Links for PTAL | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |