Basic Information
| LncRNA/CircRNA Name | PTCSC2 |
| Synonyms | NA |
| Region | GRCh38_9:97805935-97810008 |
| Ensemble | ENSG00000236130 |
| Refseq | NR_147055 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR etc. |
| Sample | PTC tissues, blood |
| Expression Pattern | down-regulated |
| Function Description | Transcripts of PTCSC2 are down-regulated in PTC tumors. We also observed a significant association of age and CLT with PTCSC2 unspliced transcript levels.Forced expression of PTCSC2 in the BCPAP cell line affected the expression of a subset of non-coding and coding transcripts with enrichment of genes functionally involved in cell cycle and cancer. |
| Pubmed ID | 25303483 |
| Year | 2014 |
| Title | Genetic Predisposition to Papillary Thyroid Carcinoma: Involvement of FOXE1, TSHR, and a Novel lincRNA Gene, PTCSC2. |
External Links
| Links for PTCSC2 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |