Basic Information
| LncRNA/CircRNA Name | PTCSC3 |
| Synonyms | NA |
| Region | GRCh38_14:36136108-36176468 |
| Ensemble | ENSG00000259104 |
| Refseq | NR_049735 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | RT-qPCR |
| Sample | cancer and paracancerous tissues,SNU-1 and Hs 746T human gastric cancer cell lines |
| Expression Pattern | down-regulated |
| Function Description | PTCSC3 and lncRNA Linc-pint were both downregulated in tumor tissues than in adjacent healthy tissues of gastric cancer patients. Low levels of PTCSC3 and Linc-pint were closely correlated with poor survival. PTCSC3 and Linc-pint overexpression inhibited tumor growth and cancer cell stemness, while Linc-pint knockdown played an opposite role an attenuated the effects of PTCSC3 overexpression. Expression levels of PTCSC3 and Linc-pint were significantly correlated in tumor tissues but not in adjacent healthy tissues. |
| Pubmed ID | 31849528 |
| Year | 2019 |
| Title | LncRNA PTCSC3 Inhibits Tumor Growth and Cancer Cell Stemness in Gastric Cancer by Interacting With lncRNA Linc-pint |
External Links
| Links for PTCSC3 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |