Basic Information
| LncRNA/CircRNA Name | BCYRN1 |
| Synonyms | Brain Cytoplasmic RNA 1 |
| Region | NA |
| Ensemble | ENSG00000236824 |
| Refseq | NR_001568 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qRT-PCR, Dual luciferase reporter assay, Western bolt |
| Sample | Normal cell line L-02 and four HCC cell lines including HepG2, Huh7, Hep3B, and BEL-7402 |
| Expression Pattern | up-regulated |
| Function Description | BCYRN1 was over expressed in HCC samples, which was connected with unfavorable prognosis in HCC patients. In addition, a series of experiments exhibited that overexpression of BCYRN1 significantly expedited HCC cells growth, clone formation, and movement abilities, and vice versa. Moreover, targeted relationships between BCYRN1 and miR-490-3p, as well as miR-490-3p and POU3F2 were affirmed by dual luciferase assay. |
| Pubmed ID | 31920461 |
| Year | 2020 |
| Title | LncRNA BCYRN1/miR-490-3p/POU3F2, Served as a ceRNA Network, Is Connected With Worse Survival Rate of Hepatocellular Carcinoma Patients and Promotes Tumor Cell Growth and Metastasis |
External Links
| Links for BCYRN1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |