Basic Information
| LncRNA/CircRNA Name | PTCSC3 |
| Synonyms | NA |
| Region | GRCh38_14:36136108-36176468 |
| Ensemble | ENSG00000259104 |
| Refseq | NR_049735 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot etc. |
| Sample | cervical cancer tissues and normal cervical tissues ,human cervical cancer cell lines C-33A and Hela cells |
| Expression Pattern | down-regulated |
| Function Description | Quantitative RT-PCR showed a down-regulation of PTCSC3 in cervical cancer tissues compared with normal cervical tissues.PTCSC3 was overexpressed in cervical cancer cell lines C-33A and Hela.Overexpression of lncRNA PTCSC3 inhibited cell proliferation, induced cell cycle arrest, and suppressed cell invasion and migration.PTCSC3 overexpression decreased the expression of cyclinD1, matrix metalloproteinases 9 (MMP9), N-cadherin and ?-catenin and increased E-cadherin expression.PTCSC3 inhibited cell growth and metastasis via sponging miR-574-5p in cervical cancer. |
| Pubmed ID | 31587336 |
| Year | 2019 |
| Title | LncRNA PTCSC3 Inhibits the Proliferation, Invasion and Migration of Cervical Cancer Cells via Sponging miR-574-5p |
External Links
| Links for PTCSC3 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |