Basic Information
| LncRNA/CircRNA Name | PTCSC3 |
| Synonyms | NA |
| Region | GRCh38_14:36136108-36176468 |
| Ensemble | ENSG00000259104 |
| Refseq | NR_049735 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | thyroid cancer |
| ICD-0-3 | C73.9 |
| Methods | qPCR etc. |
| Sample | thyroid cancer tissues, cell lines (BCPAP, FTC133, 8505C etc.) |
| Expression Pattern | differential expression |
| Function Description | Following transfection with PTCSC3, all three thyroid cancer cells originating from various pathological types of thyroid cancers demonstrated significant growth inhibition, cell cycle arrest and increased apoptosis. So PTCSC3 as a tumor suppressor was investigated as a competing endogenous RNA for miR-574-5p. |
| Pubmed ID | 23599737 |
| Year | 2013 |
| Title | A long non-coding RNA, PTCSC3, as a tumor suppressor and a target of miRNAs in thyroid cancer cells. |
External Links
| Links for PTCSC3 | GenBank HGNC NONCODE |
| Links for thyroid cancer | OMIM COSMIC |