Basic Information
| LncRNA/CircRNA Name | PTENP1 |
| Synonyms | PTENP1, PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN |
| Region | GRCh38_9:33673504-33677499 |
| Ensemble | ENSG00000237984 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | low-grade gliomas (LGGs, nine grade I and four grade II tumors) and 10 high-grade gliomas (four grade III and six grade IV tumors), SHG44 and U251 human glioma cells |
| Expression Pattern | down-regulated |
| Function Description | expression of lncRNA PTENP1 was decreased in glioma tissues when compared with normal brain tissues. Overexpression of PTENP1 suppressed SHG44 and U251 cell proliferation and significantly decreased the numbers of S-phase cells. Furthermore, the invasion and migration abilities of SHG44 and U251 cells were reduced after being transfected with a PTENP1 overexpression plasmid. Overexpression of PTENP1 induced the expression of p21 protein and suppressed the p38 signaling pathway. |
| Pubmed ID | 30613153 |
| Year | 2019 |
| Title | Overexpression of lncRNA PTENP1 suppresses glioma cell proliferation and metastasis in vitro |
External Links
| Links for PTENP1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |