Basic Information
| LncRNA/CircRNA Name | PTENP1 |
| Synonyms | PTENP1, PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN |
| Region | GRCh38_9:33673504-33677499 |
| Ensemble | ENSG00000237984 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, Dual luciferase reporter assay, Cell proliferation assay etc. |
| Sample | cell lines (293T, PC3) |
| Expression Pattern | down-regulated |
| Function Description | We find that PTENP1 is biologically active as it can regulate cellular levels of PTEN and exert a growth-suppressive role. We also show that the PTENP1 locus is selectively lost in human cancer. |
| Pubmed ID | 20577206 |
| Year | 2010 |
| Title | A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. |
External Links
| Links for PTENP1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |