Basic Information
| LncRNA/CircRNA Name | BCYRN1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | ENSG00000236824 |
| Refseq | NR_001568 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, in vitro knockdown, etc. |
| Sample | human NSCLC cell lines (A549, SPC-A1, H460 and H1650) and a normal human bronchial epithelial cell line (16HBE) |
| Expression Pattern | up-regulated |
| Function Description | BCYRN1 was increased in NSCLC, and its downregulated expression could suppress NSCLC cell proliferation and cell cycle progression by inhibiting the Wnt/-catenin pathway. Our results showed that the expression of BCYRN1 was higher in lung cancer cells compared with a normal bronchial epithelial cell line. Moreover, downregulation of BCYRN1 expression could inhibit cell proliferation and migration and induce apoptosis. Knockdown of BCYRN1 in NSCLC cells reduced a cohort of molecules (-catenin, c-Myc and cyclin D1) which are critical for cell proliferation and apoptosis. Our results suggested that BCYRN1 induces the proliferation and migration of NSCLC cells and plays an important role in NSCLC progression. |
| Pubmed ID | 30486938 |
| Year | 2019 |
| Title | Long Non-Coding RNA Brain Cytoplasmic RNA 1 Acts as an Oncogene and Regulates Cell Proliferation and Metastasis in Non-Small Cell Lung Cancer |
External Links
| Links for BCYRN1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |