Basic Information
| LncRNA/CircRNA Name | PTENP1 |
| Synonyms | PTENP1, PTEN-rs, PTEN2, PTENpg1, PTH2, psiPTEN |
| Region | GRCh38_9:33673504-33677499 |
| Ensemble | ENSG00000237984 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Western blots, qPCR, Luciferase reporter assay, RIP etc. |
| Sample | HCC tissue, cell lines (Sk-Hep-1, SMMC-7721) |
| Expression Pattern | up-regulated |
| Function Description | PTENP1 level in the HCC tissues was significantly lower compared with those in the adjacent normal tissues. And PTENP1 was able to repress cell invasion, metastasis, and proliferation capacity in HCC cell lines. The overexpression of PTENP1 inhibited HCC growth both in vitro and in vivo. There were a binding sequence and direct interaction between PTENP1 and miR-193a-3p. PTENP1 as an endogenous sponge interacted with miR-193a-3p, leading to regulate the downstream PTEN/Akt pathway. |
| Pubmed ID | 29296207 |
| Year | 2017 |
| Title | Long non-coding RNA PTENP1 interacts with miR-193a-3p to suppress cell migration and invasion through the PTEN pathway in hepatocellular carcinoma |
External Links
| Links for PTENP1 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |