Basic Information
| LncRNA/CircRNA Name | PTTG3P |
| Synonyms | PTTG3??cPTTG1 |
| Region | GRCh38_8:66767400-66768005 |
| Ensemble | ENSG00000213005 |
| Refseq | NR_002734 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | 2 | ||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, Western blot, in vitro knockdown |
| Sample | hepatocellular carcinoma tissues, cell lines (HepG2 and Hep3B) |
| Expression Pattern | up-regulated |
| Function Description | PTTG3P was frequently up-regulated in HCC and its level was correlated to tumor size, TNM stage and poor survival of patients with HCC. Enforced expression of PTTG3P significantly promoted cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. Conversely, PTTG3P knockdown had opposite effects. Mechanistically, over-expression of PTTG3P up-regulated PTTG1, activated PI3K/AKT signaling and its downstream signals including cell cycle progression, cell apoptosis and epithelial-mesenchymal transition (EMT)-associated genes. |
| Pubmed ID | 29803224 |
| Year | 2018 |
| Title | The Long Non-Coding RNA PTTG3P Promotes Cell Growth and Metastasis via Up-Regulating PTTG1 and Activating PI3K/AKT Signaling in Hepatocellular Carcinoma |
External Links
| Links for PTTG3P | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |