Basic Information
| LncRNA/CircRNA Name | BCYRN1 |
| Synonyms | BCYRN1, BC200, BC200a, LINC00004, NCRNA00004 |
| Region | GRCh38_2:47335315-47335514 |
| Ensemble | ENSG00000236824 |
| Refseq | NR_001568 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | cervical cancer |
| ICD-0-3 | C53 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (SiHa, HeLa, CaSki, Ect1/E6E7), cervical cancer tissues |
| Expression Pattern | up-regulated |
| Function Description | MicroRNA (miR)-138 was predicted as a direct target of BCYRN1 and the expression of miR-138 was elevated in HeLa cells transfected with BCYRN1 siRNA. Subsequently, elevated levels of miR-138 were suppressed by transfection with miR-138 inhibitor in HeLa cells pretreated with BCYRN1 siRNA. BCYRN1 siRNA partially counteracted the effect of miR-138 inhibitor on promoting cell viability and mobility in HeLa cells. BCYRN1 siRNA was able to prevent tumor growth, and reduced the expression of migration marker proteins metalloproteinase 2 and vascular endothelial cell growth factor, with enhanced expression levels of miR-138. These results suggest that lncRNA BCYRN1 promotes the proliferation and invasion of cervical cancer via targeting miR-138. |
| Pubmed ID | 29552212 |
| Year | 2018 |
| Title | Long non-coding RNA BCYRN1 promotes the proliferation and metastasis of cervical cancer via targeting microRNA-138 in vitro and in vivo. |
External Links
| Links for BCYRN1 | GenBank HGNC NONCODE |
| Links for cervical cancer | OMIM COSMIC |