Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay etc |
| Sample | NSCLC tissues, cell lines (H1650, H1975, H460 and A549) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 and SOX9 was highly expressed in NSCLC tumor tissues and cells. PVT1 facilitated proliferation, migration, invasion and hindered apoptosis of NSCLC cells. MiR-361-3p was a target of PVT1 in NSCLC cells. SOX9 acted as a target of miR-361-3p. PVT1 worked as a miR-361-3p sponge to regulate SOX9 expression. PVT1 modulate the Wnt/?-catenin Signaling Pathway by miR-361-3p/SOX9 axis. Our studies disclosed that PVT1 boosted proliferation, migration, invasion and curbed apoptosis by miR-361-3p/SOX9 axis, providing the possible therapeutic strategy for NSCLC. |
| Pubmed ID | 32197208 |
| Year | 2020 |
| Title | Long Non-Coding RNA PVT1 Contributes to Cell Growth and Metastasis in Non-Small-Cell Lung Cancer by Regulating miR-361-3p/SOX9 Axis and Activating Wnt/?-catenin Signaling Pathway |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |