Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Non Small Cell Lung Cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Luciferase reporter assay, RIP, Western blot |
| Sample | NSCLC tissues,cell lines(A549,H157 ,A460, SPC-A-1,LTEP-a-2) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was the most remarkable lncRNA that upregulated in NSCLC. CARM1 co-expressed with lncRNA PVT1 and associated with NSCLC radiosensitivity. |
| Pubmed ID | 30861415 |
| Year | 2019 |
| Title | Long Non-coding RNA PVT1 Competitively Binds MicroRNA-424-5p to Regulate CARM1 in Radiosensitivity of Non-Small-Cell Lung Cancer. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for Non Small Cell Lung Cancer | OMIM COSMIC |