Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | plasmacytoma variant translocation 1 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | qRT-PCR, Western blot analysis, Dual Luciferase Reporter Assay, RIP |
| Sample | EC tissues,EC cell lines KYSE-30, KYSE-70, KYSE-109, Eca109, TE-1, and normal esophageal epithelial cell line HEEC |
| Expression Pattern | up-regulated |
| Function Description | downregulation of lncRNA PVT1 can induce the overexpression of miR-145 thus inhibiting cell viability, migration, and invasion, affecting cell cycle and accelerating apoptosis of EC via knockdown of FSCN1. |
| Pubmed ID | 31951853 |
| Year | 2020 |
| Title | Silencing lncRNAs PVT1 Upregulates miR-145 and Confers Inhibitory Effects on Viability, Invasion, and Migration in EC |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |