Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | plasmacytoma variant translocation 1 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, RIP |
| Sample | U87 and LN229 cells |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was upregulated in glioma tissues relative to controls. Its level was higher in glioma patients with advanced stage or accompanied by metastasis. The glioma patients with a high level of PVT1 suffered a worse prognosis. The overexpression of PVT1 accelerated proliferative and migratory abilities of U87 and LN229 cells.PVT1 accelerates the proliferative and migratory abilities of glioma via downregulating UPF1. |
| Pubmed ID | 31696483 |
| Year | 2019 |
| Title | LncRNA PVT1 Aggravates the Progression of Glioma via Downregulating UPF1 |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |