Basic Information
LncRNA/CircRNA Name | PVT1 |
Synonyms | plasmacytoma variant translocation 1 |
Region | GRCh38_8:127794533-128101253 |
Ensemble | ENSG00000249859 |
Refseq | NR_003367 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | Drug | |||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | glioma |
ICD-0-3 | NA |
Methods | qRT-PCR, RIP |
Sample | U87 and LN229 cells |
Expression Pattern | up-regulated |
Function Description | PVT1 was upregulated in glioma tissues relative to controls. Its level was higher in glioma patients with advanced stage or accompanied by metastasis. The glioma patients with a high level of PVT1 suffered a worse prognosis. The overexpression of PVT1 accelerated proliferative and migratory abilities of U87 and LN229 cells.PVT1 accelerates the proliferative and migratory abilities of glioma via downregulating UPF1. |
Pubmed ID | 31696483 |
Year | 2019 |
Title | LncRNA PVT1 Aggravates the Progression of Glioma via Downregulating UPF1 |
External Links
Links for PVT1 | GenBank HGNC NONCODE |
Links for glioma | OMIM COSMIC |