Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | nasopharyngeal cancer |
| ICD-0-3 | C11 |
| Methods | qPCR, Western blot |
| Sample | nasopharyngeal carcinoma tissues, cell lines(5-8F, HNE1, HNE2, CNE1, CNE2, NP69 ) |
| Expression Pattern | up-regulated |
| Function Description | PVT1 was significantly up-regulated in both NPC tissues and cell lines and associated with poor prognosis. PVT1 negatively regulates the expression levels of miR-1207 in NPC cells and spheres cells. |
| Pubmed ID | 30141114 |
| Year | 2018 |
| Title | Non-Coding RNA Pvt1 Promotes Cancer Stem Cell-Like Traits in Nasopharyngeal Cancer via Inhibiting miR-1207. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for nasopharyngeal cancer | OMIM COSMIC |