Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | NA |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | endometrial cancer |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, luciferase reporter assay |
| Sample | endometrial cancer tissues, cell lines (HEC-1A, 293T) |
| Expression Pattern | up-regulated |
| Function Description | Quantitative real-time PCR and fluorescence in situ hybridization (FISH)3 demonstrated that PVT1 is up-regulated concomitant with miR-195-5p down-regulation in human endometrial carcinoma tissues. PVT1 knockdown inhibited cell proliferation, migration, and invasion while facilitating apoptosis of endometrial cancer cells. |
| Pubmed ID | 30031900 |
| Year | 2018 |
| Title | Long Non-Coding RNA PVT1 Promotes Malignancy in Human Endometrial Carcinoma Cells Through Negative Regulation of miR-195-5p. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for endometrial cancer | OMIM COSMIC |