Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | LINC00079, MIR1204HG, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, other |
| Sample | ovarian cancer tissues and cell lines (A2780, TOV112D, HO-8910, OVCAR-3, and SKOV3), 1 normal ovarian cell line (ISOE80) and the 293T cell line |
| Expression Pattern | up-regulated |
| Function Description | Compared with normal tissues, the expression of lnc-PVT1 T1 was remarkably upregulated in tumor tissues. Moreover, the proliferation and invasion of ovarian cancer were promoted after knockdown of lnc-PVT1 in vitro. Moreover, both the mRNA and protein levels of SOX2 were suppressed after knockdown of lnc-PVT1 in vitro. Besides, the expression of SOX2 in tumor tissues was positively correlated to lnc-PVT1. |
| Pubmed ID | 30468460 |
| Year | 2018 |
| Title | Long Non-Coding RNA PVT1 Functions as an Oncogene in Ovarian Cancer via Upregulating SOX2 |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |