Basic Information
LncRNA/CircRNA Name | PVT1 |
Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
Region | GRCh38_8:127794533-128101253 |
Ensemble | ENSG00000249859 |
Refseq | NR_003367 |
Classification Information
Regulatory Mechanism | Biological Function | Clinical Application | |||
---|---|---|---|---|---|
TF | Immune | Survival | |||
Enhancer | Apoptosis | apoptosis | Drug | ||
Variant | Cell Growth | Circulating | |||
MiRNA | EMT | Metastasis | |||
Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
Cancer Name | laryngeal squamous cell cancer |
ICD-0-3 | C32.3 |
Methods | qPCR, Western blot, Luciferase reporter assay, Microarray, other |
Sample | LSCC tissues and cell lines (TU686, TU177,and LSC-1) |
Expression Pattern | up-regulated |
Function Description | Upregulation of lncRNA PVT1 markedly facilitated proliferation suppressed apoptosis and promoted cell migration in LSCC cells. We further demonstrated that silencing PVT1 strikingly suppressed proliferation, promoted apoptosis, and reduced migration in LSCC cells. Further bioinformatic analysis and dual-luciferase reporter assay revealed that PVT1 could function as an oncogenic transcript partly through sponging miR-519d-3p. Besides, mechanistic investigations indicated that PVT1 could promote cell and migration through interacting with miR-519d-3p. |
Pubmed ID | 30304557 |
Year | 2019 |
Title | Long Noncoding RNA PVT1 Promotes Laryngeal Squamous Cell Carcinoma Development by Acting as a Molecular Sponge to Regulate miR-519d-3p |
External Links
Links for PVT1 | GenBank HGNC NONCODE |
Links for laryngeal squamous cell cancer | OMIM COSMIC |