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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	cervical cancer
ICD-0-3	C53
Methods	qPCR, Western blot, Luciferase reporter assay
Sample	H8 cell line (the human cervical epithelial immortalized cell line), cervical cancer cell lines, HeLa, Ca Ski and SiHa
Expression Pattern	up-regulated
Function Description	LncRNA PVT1 overexpression accelerated the growth of cervical cancer cells by advancing the cell cycle and inhibiting cellular apoptosis; increases in Cyclin D1 (CCND1) mRNA and activated Bcl-2 protein expression levels also supported this finding. Furthermore, NF-?B activation and expression was increased by LncRNA PVT1 overexpression. In addition, NF-?B activation or inhibition induced changes in cell viability, accompanied by changes in CCND1 and Bcl-2 expression. Increases or decreases in microRNA-16 (miR-16) expression (using miR mimics and inhibitors) also corresponded to changes in LncRNA PVT1 expression, in vitro. miR-16 mimics and inhibitor had opposite effects to those of NF-?B activity, and miR-16 was demonstrated to directly interact with the NF-?B gene as measured using the dual-luciferase assay.
Pubmed ID	31322217
Year	2019
Title	Long non-coding RNA plasmacytoma variant translocation 1 gene promotes the development of cervical cancer via the NF-?B pathway

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