Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy0 | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | uveal melanoma |
| ICD-0-3 | C69.9 |
| Methods | other |
| Sample | OS tissues |
| Expression Pattern | up-regulated |
| Function Description | high PVT1 expression group had a higher proportion of epithelioid cell dominant disease (a more malignant histological subtype than spindle cell dominant disease) and more cases of extrascleral extension (a risk factor for metastasis), PVT1 expression was strongly and negatively correlated with its methylation status.high PVT1 expression was an independent predictor of poor OS in patients with uveal melanoma.PVT1 expression is modulated by both DNA amplification and methylation and its expression might serve as a valuable and specific prognostic biomarker in terms of OS in uveal melanoma. |
| Pubmed ID | 29244840 |
| Year | 2017 |
| Title | High expression of lncRNA PVT1 independently predicts poor overall survival in patients with primary uveal melanoma. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for uveal melanoma | OMIM COSMIC |