Basic Information
| LncRNA/CircRNA Name | BDNF-AS |
| Synonyms | NA |
| Region | GRCh38_11:27506838-27698174 |
| Ensemble | ENSG00000245573 |
| Refseq | NR_002832 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blotting, RIP etc. |
| Sample | 20 pairs of CRC and paracancerous tissues??wo types of human CRC cells (HCT116 and LoVo) |
| Expression Pattern | down-regulated |
| Function Description | LncRNA BDNF-AS expression was significantly decreased, while GSK-3? was highly expressed in human CRC tissues and cell lines. Moreover, lncRNA BDNF-AS induced inhibition of proliferation, migration, and invasion of CRC cells via inhibiting GSK-3? expression. Mechanistically, BDNF-AS led to GSK-3? promoter silencing in CRC cells through recruitment of EZH2. |
| Pubmed ID | 31062382 |
| Year | 2019 |
| Title | LncRNA BDNF-AS suppresses colorectal cancer cell proliferation and migration by epigenetically repressing GSK-3? expression |
External Links
| Links for BDNF-AS | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |