Basic Information
| LncRNA/CircRNA Name | PVT1 |
| Synonyms | PVT1, LINC00079, MYC, NCRNA00079, onco-lncRNA-100 |
| Region | GRCh38_8:127794533-128101253 |
| Ensemble | ENSG00000249859 |
| Refseq | NR_003367 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | papillary thyroid cancer |
| ICD-0-3 | NA |
| Methods | qPCR, in vitro knockdown etc. |
| Sample | cell line (TPC2), FFPE tissue |
| Expression Pattern | up-regulated |
| Function Description | Downregulation of PVT1 decreased the recruitment of the transcriptional factor EZH2 in several thyroid cancer cell lines, resulting in decreased expression of cyclin D1 and thyroid-stimulating hormone receptor (TSHR). |
| Pubmed ID | 29280051 |
| Year | 2017 |
| Title | Long Non-coding RNA Linc-ROR Is Upregulated in Papillary Thyroid Carcinoma. |
External Links
| Links for PVT1 | GenBank HGNC NONCODE |
| Links for papillary thyroid cancer | OMIM COSMIC |